Category: Blog

**1.** What is ‘Fetal Fraction’ and What Does it Mean for Your Non …

May 21, 2019 — Fetal fraction is the term given to the proportion of cfDNA belonging to the placenta found in the mother’s blood. In order to perform NIPT, there ^{(1)}…

by G Ashoor · 2013 · Cited by 372 — The median fetal fraction was 10.0% (interquartile range, 7.8-13.0%) and this decreased with maternal weight from 11.7% at 60 kg to 3.9% at 160 kg. The ^{(2)}…

by JA Canick · 2013 · Cited by 302 — The proportion derived from the placenta is known as the fetal fraction. When measured between 10 and 20 gestational weeks, the average fetal fraction in the ^{(3)}…

**2.** fetal fraction facts – VCGS

Apr 3, 2017 — both maternal and fetal in origin (1). Both components are analysed during non-invasive prenatal testing (NIPT). What is fetal fraction?^{(4)}…

by Y Hou · 2019 · Cited by 7 — Fetal fraction is known to be affected by gestational age, maternal weight, placental size and function, and other various factors. Study showed ^{(5)}…

The fetal fraction (FF), i.e. the amount of fetal cfDNA detected in the plasma sample analysed compared to the total cfDNA, is an important parameter to determine ^{(6)}…

**3.** What is noninvasive prenatal testing (NIPT) and what …

The proportion of cfDNA in maternal blood that comes from the placenta is known as the fetal fraction. Generally, the fetal fraction must be above 4 percent, ^{(7)}…

Nov 13, 2019 — The fetal fraction (FF)—the amount of fetal cfDNA divided by the total amount of fetal and maternal cfDNA in the circulation—is reported on most ^{(8)}…

**4.** Fetal fraction evaluation in non-invasive prenatal screening …

by MS Hestand · 2019 · Cited by 17 — Non-invasive prenatal screening (NIPS) or testing (NIPT) for aneuploidy detection should be evaluated for sufficient fetal DNA fraction (FF) since ^{(9)}…

by NC Welker · 2020 · Cited by 3 — A primary driver of NIPS sensitivity for aneuploidy in a given maternal plasma sample is the fetal fraction (FF), which describes the proportion of ^{(10)}…

Nov 30, 2020 — The fetal fraction determination is based on single nucleotide polymorphism (SNP) profiling and minor allele frequency assessment.^{(11)}…

Mar 19, 2014 — Report Indicates: “Low fetal fraction”: Panorama works by looking at of the DNA in the mother’s blood is from the fetus (i.e. 10% fetal fraction) ^{(12)}…

by I Krishna · 2015 — pregnant women with a low fetal fraction compared with women who had a sufficient fetal fraction on noninvasive prenatal testing. (NIPT) results.^{(13)}…

**5.** Variability of “Reported Fetal Fraction” in Noninvasive …

by F Persson — AbstractBackground. Fetal fraction is often used to designate no-calls in noninvasive prenatal screening (NIPS). We wished to compare the ^{(14)}…

by M Ali · 2017 — INTRODUCTION: Placental-origin cell-free maternal DNA is known as the fetal fraction (FF). Low FF is a risk factor for aneuploidy, and ^{(15)}…

A noninvasive prenatal test (NIPT) analyzes cfDNA from a maternal blood sample to screen for common chromosomal conditions in the fetus. Fetal Fraction. The ^{(16)}…

**6.** What is an NIPT Test? | SneakPeek® – Gender Blood Test

Jan 12, 2021 — The percent of cffDNA in your blood is known as the fetal fraction, which increases the further along you are in pregnancy. Around 10-12 weeks, ^{(17)}…

by D Adiyaman · 2020 — To investigate the possible predictive value of fetal fraction in the cell-free DNA (cfDNA) test in pregnancies with early- and late-onset fetal ^{(18)}…

by CA Struble · 2014 · Cited by 54 — Objective: To estimate fetal fraction (FF) in monozygotic and dizygotic Keywords: Cell-free DNA testingPrenatal diagnosisFetal aneuploidy ^{(19)}…

Oct 14, 2020 — Application of FF-QuantSC for the Precise Estimation of Fetal Fraction in Non-invasive Prenatal Testing in Two SRY-Translocation Cases. Yan ^{(20)}…

**7.** Module 6: NGS and Fetal Fraction

Module 6: NGS and Fetal Fraction. Next generation sequencing (NGS). • In an unaffected pregnancy, chromosome 21 represents. 1.36% of the total cell-free ^{(21)}…

by AN Barrett · 2017 · Cited by 18 — Good correlation was found between fetal fraction using indels and using whole genome sequencing of the Y chromosome (Spearmans r ^{(22)}…

The proportion derived from the placenta is known as the fetal fraction. When measured between 10 and 20 gestational weeks, the average fetal fraction in ^{(23)}…

**8.** Cost-effective method to measure fetal fraction … – IEEE Xplore

by S Kim · 2020 — ABSTRACT The accurate measure of fetal fraction is important to ensure the results of noninvasive prenatal testing. However, measuring fetal fraction could ^{(24)}…

by L Qiao · 2019 · Cited by 12 — Shorter fragment size was the key factor affecting fetal fraction in multivariable linear regression models as well as to validate the accuracy of the size selection for ^{(25)}…

by E Wang · 2013 · Cited by 395 — The Harmony Prenatal Test determined fetal percentage via directed analysis Table 1 shows the fraction of samples having at least 4% fetal. cfDNA in relation ^{(26)}…

**9.** The fetal fraction of cell-free DNA in maternal plasma is not …

by H Brar · 2013 · Cited by 44 — Objective: To determine the relationship between a priori risk for fetal trisomy and the fraction of fetal cell-free DNA (cfDNA) in maternal blood. Methods: A ^{(27)}…

by C Zhao · 2015 · Cited by 134 — syndrome is constrained by 4 factors: fetal fraction, MD size, coverage, and biological and technical variability of the event region. Our algorithm takes these ^{(28)}…

**10.** Chapter 5 Calculating the fetal fraction for noninvasive …

by R Straver · Cited by 57 — Calculating the fetal fraction for noninvasive prenatal testing based on genome-wide nucleosome profiles. Roy Straver, Cees B.M. Oudejans, Erik A. Sistermans ^{(29)}…

The fetal fraction (FF) is a function of both biological factors and bioinformatics algorithms used to interpret DNA sequencing results. It is an essential quality control ^{(30)}…

## Excerpt Links

(1). What is ‘Fetal Fraction’ and What Does it Mean for Your Non …

(2). Fetal fraction in maternal plasma cell-free DNA at 11-13 …

(3). The impact of maternal plasma DNA fetal fraction on … – PubMed

(4). fetal fraction facts – VCGS

(5). Factors affecting cell-free DNA fetal fraction: statistical analysis …

(6). Fetal fraction determination – PrenatalSAFE

(7). What is noninvasive prenatal testing (NIPT) and what …

(8). High Fetal Fraction in First Trimester May Be Useful Marker of …

(9). Fetal fraction evaluation in non-invasive prenatal screening …

(10). High-throughput fetal fraction amplification increases … – Nature

(11). An online tool for fetal fraction prediction based on direct size …

(12). Patient Guide to Results – ARUP Laboratories

(13). Perinatal outcomes in pregnancies with a low fetal fraction on …

(14). Variability of “Reported Fetal Fraction” in Noninvasive …

(15). Perinatal Outcomes in Pregnancies With a Low Fetal Fraction …

(16). Cell-Free DNA Technology, Fetal Fraction, & NIPT – Illumina

(17). What is an NIPT Test? | SneakPeek® – Gender Blood Test

(18). Can fetal fractions in the cell-free DNA test predict the onset of …

(19). Fetal Fraction Estimate in Twin Pregnancies Using Directed …

(20). Application of FF-QuantSC for the Precise … – Frontiers

(21). Module 6: NGS and Fetal Fraction

(22). Measurement of fetal fraction in cell-free DNA from maternal …

(23). The impact of maternal plasma DNA fetal fraction on next …

(24). Cost-effective method to measure fetal fraction … – IEEE Xplore

(25). Sequencing shorter cfDNA fragments improves the fetal DNA …

(26). Gestational age and maternal weight effects on … – Otogenetics

(27). The fetal fraction of cell-free DNA in maternal plasma is not …

(28). Detection of Fetal Subchromosomal Abnormalities by …

(29). Chapter 5 Calculating the fetal fraction for noninvasive …

(30). Fetal fraction and noninvasive prenatal testing: What clinicians …