Category: Blog
1. What is ‘Fetal Fraction’ and What Does it Mean for Your Non …
May 21, 2019 — Fetal fraction is the term given to the proportion of cfDNA belonging to the placenta found in the mother’s blood. In order to perform NIPT, there (1)…
by G Ashoor · 2013 · Cited by 372 — The median fetal fraction was 10.0% (interquartile range, 7.8-13.0%) and this decreased with maternal weight from 11.7% at 60 kg to 3.9% at 160 kg. The (2)…
by JA Canick · 2013 · Cited by 302 — The proportion derived from the placenta is known as the fetal fraction. When measured between 10 and 20 gestational weeks, the average fetal fraction in the (3)…
2. fetal fraction facts – VCGS
Apr 3, 2017 — both maternal and fetal in origin (1). Both components are analysed during non-invasive prenatal testing (NIPT). What is fetal fraction?(4)…
by Y Hou · 2019 · Cited by 7 — Fetal fraction is known to be affected by gestational age, maternal weight, placental size and function, and other various factors. Study showed (5)…
The fetal fraction (FF), i.e. the amount of fetal cfDNA detected in the plasma sample analysed compared to the total cfDNA, is an important parameter to determine (6)…
3. What is noninvasive prenatal testing (NIPT) and what …
The proportion of cfDNA in maternal blood that comes from the placenta is known as the fetal fraction. Generally, the fetal fraction must be above 4 percent, (7)…
Nov 13, 2019 — The fetal fraction (FF)—the amount of fetal cfDNA divided by the total amount of fetal and maternal cfDNA in the circulation—is reported on most (8)…
4. Fetal fraction evaluation in non-invasive prenatal screening …
by MS Hestand · 2019 · Cited by 17 — Non-invasive prenatal screening (NIPS) or testing (NIPT) for aneuploidy detection should be evaluated for sufficient fetal DNA fraction (FF) since (9)…
by NC Welker · 2020 · Cited by 3 — A primary driver of NIPS sensitivity for aneuploidy in a given maternal plasma sample is the fetal fraction (FF), which describes the proportion of (10)…
Nov 30, 2020 — The fetal fraction determination is based on single nucleotide polymorphism (SNP) profiling and minor allele frequency assessment.(11)…
Mar 19, 2014 — Report Indicates: “Low fetal fraction”: Panorama works by looking at of the DNA in the mother’s blood is from the fetus (i.e. 10% fetal fraction) (12)…
by I Krishna · 2015 — pregnant women with a low fetal fraction compared with women who had a sufficient fetal fraction on noninvasive prenatal testing. (NIPT) results.(13)…
5. Variability of “Reported Fetal Fraction” in Noninvasive …
by F Persson — AbstractBackground. Fetal fraction is often used to designate no-calls in noninvasive prenatal screening (NIPS). We wished to compare the (14)…
by M Ali · 2017 — INTRODUCTION: Placental-origin cell-free maternal DNA is known as the fetal fraction (FF). Low FF is a risk factor for aneuploidy, and (15)…
A noninvasive prenatal test (NIPT) analyzes cfDNA from a maternal blood sample to screen for common chromosomal conditions in the fetus. Fetal Fraction. The (16)…
6. What is an NIPT Test? | SneakPeek® – Gender Blood Test
Jan 12, 2021 — The percent of cffDNA in your blood is known as the fetal fraction, which increases the further along you are in pregnancy. Around 10-12 weeks, (17)…
by D Adiyaman · 2020 — To investigate the possible predictive value of fetal fraction in the cell-free DNA (cfDNA) test in pregnancies with early- and late-onset fetal (18)…
by CA Struble · 2014 · Cited by 54 — Objective: To estimate fetal fraction (FF) in monozygotic and dizygotic Keywords: Cell-free DNA testingPrenatal diagnosisFetal aneuploidy (19)…
Oct 14, 2020 — Application of FF-QuantSC for the Precise Estimation of Fetal Fraction in Non-invasive Prenatal Testing in Two SRY-Translocation Cases. Yan (20)…
7. Module 6: NGS and Fetal Fraction
Module 6: NGS and Fetal Fraction. Next generation sequencing (NGS). • In an unaffected pregnancy, chromosome 21 represents. 1.36% of the total cell-free (21)…
by AN Barrett · 2017 · Cited by 18 — Good correlation was found between fetal fraction using indels and using whole genome sequencing of the Y chromosome (Spearmans r (22)…
The proportion derived from the placenta is known as the fetal fraction. When measured between 10 and 20 gestational weeks, the average fetal fraction in (23)…
8. Cost-effective method to measure fetal fraction … – IEEE Xplore
by S Kim · 2020 — ABSTRACT The accurate measure of fetal fraction is important to ensure the results of noninvasive prenatal testing. However, measuring fetal fraction could (24)…
by L Qiao · 2019 · Cited by 12 — Shorter fragment size was the key factor affecting fetal fraction in multivariable linear regression models as well as to validate the accuracy of the size selection for (25)…
by E Wang · 2013 · Cited by 395 — The Harmony Prenatal Test determined fetal percentage via directed analysis Table 1 shows the fraction of samples having at least 4% fetal. cfDNA in relation (26)…
9. The fetal fraction of cell-free DNA in maternal plasma is not …
by H Brar · 2013 · Cited by 44 — Objective: To determine the relationship between a priori risk for fetal trisomy and the fraction of fetal cell-free DNA (cfDNA) in maternal blood. Methods: A (27)…
by C Zhao · 2015 · Cited by 134 — syndrome is constrained by 4 factors: fetal fraction, MD size, coverage, and biological and technical variability of the event region. Our algorithm takes these (28)…
10. Chapter 5 Calculating the fetal fraction for noninvasive …
by R Straver · Cited by 57 — Calculating the fetal fraction for noninvasive prenatal testing based on genome-wide nucleosome profiles. Roy Straver, Cees B.M. Oudejans, Erik A. Sistermans (29)…
The fetal fraction (FF) is a function of both biological factors and bioinformatics algorithms used to interpret DNA sequencing results. It is an essential quality control (30)…
Excerpt Links
(1). What is ‘Fetal Fraction’ and What Does it Mean for Your Non …
(2). Fetal fraction in maternal plasma cell-free DNA at 11-13 …
(3). The impact of maternal plasma DNA fetal fraction on … – PubMed
(4). fetal fraction facts – VCGS
(5). Factors affecting cell-free DNA fetal fraction: statistical analysis …
(6). Fetal fraction determination – PrenatalSAFE
(7). What is noninvasive prenatal testing (NIPT) and what …
(8). High Fetal Fraction in First Trimester May Be Useful Marker of …
(9). Fetal fraction evaluation in non-invasive prenatal screening …
(10). High-throughput fetal fraction amplification increases … – Nature
(11). An online tool for fetal fraction prediction based on direct size …
(12). Patient Guide to Results – ARUP Laboratories
(13). Perinatal outcomes in pregnancies with a low fetal fraction on …
(14). Variability of “Reported Fetal Fraction” in Noninvasive …
(15). Perinatal Outcomes in Pregnancies With a Low Fetal Fraction …
(16). Cell-Free DNA Technology, Fetal Fraction, & NIPT – Illumina
(17). What is an NIPT Test? | SneakPeek® – Gender Blood Test
(18). Can fetal fractions in the cell-free DNA test predict the onset of …
(19). Fetal Fraction Estimate in Twin Pregnancies Using Directed …
(20). Application of FF-QuantSC for the Precise … – Frontiers
(21). Module 6: NGS and Fetal Fraction
(22). Measurement of fetal fraction in cell-free DNA from maternal …
(23). The impact of maternal plasma DNA fetal fraction on next …
(24). Cost-effective method to measure fetal fraction … – IEEE Xplore
(25). Sequencing shorter cfDNA fragments improves the fetal DNA …
(26). Gestational age and maternal weight effects on … – Otogenetics
(27). The fetal fraction of cell-free DNA in maternal plasma is not …
(28). Detection of Fetal Subchromosomal Abnormalities by …
(29). Chapter 5 Calculating the fetal fraction for noninvasive …
(30). Fetal fraction and noninvasive prenatal testing: What clinicians …
